The areas along the Delaware River and its tributaries in eastern Pennsylvania were long inhabited by indigenous peoples of various cultures. By the time of European contact, these areas were the historic territory of the Algonquian-speaking Lenape Nation, which had two main language families, the Unami and the Munsee. They traded with the Dutch and then English colonists in the mid-Atlantic area.
On Christmas Eve in 1741, David Nitschmann and Count Nicolaus von Zinzendorf, leading a small group of Moravians, founded the mission community of Bethlehem along the banks of the Monocacy Creek by the Lehigh River in the colony of Pennsylvania. They named the settlement after the town of Bethlehem in Judea, the birthplace of Jesus. Originally it was a typical Moravian Settlement Congregation, where the Church owned all the property. Until the 1850s, only members of the Moravian Church were permitted to lease land plots in Bethlehem. The historic Brethren's House, Sisters' House, Widows' House and Gemeinhaus (Congregation House) with the Old Chapel are remnants of this period of communal living.
The Moravians ministered to regional Lenape Native Americans through their mission in the area, as well as further east in the New York colony. In the historic Bethlehem God's Acre cemetery, converted Lenape lay buried alongside the Moravians.
In 1762, Bethlehem built the first water-works in America to pump water for public use. While George Washington and his troops stayed in Valley Forge, Washington stored his personal effects at the farm of James Burnside in Bethlehem - as of 1998 a historical museum (Burnside Plantation).
The prosperous village was incorporated into a free borough in the County of Northampton in 1845. After the Unity Synod of 1848, Bethlehem became the headquarters of the Northern Province of the Moravian Church in North America.
On March 27, 1900, the Bach Choir of Bethlehem presented the United States debut of German
