This town is famed for the Botanical Expedition on the New Kingdom of Granada which commenced from there in 1783 led by the biologist José Celestino Mutis. The expedition researched local fauna and flora. It was also an important trade centre during the 19th and part of the 20th century.
Originally La Mesa was located a short distance from its present location and was known as Guayabal. But because of lack of
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