The Attawandaron, or Neutral Nation, lived in the Grand River valley area before the 17th century; their main village and seat of the chief, Kandoucho, was identified by 19th-century historians as having been located on the Grand River where Brantford lies today. This town, like the rest of their settlements, was destroyed when the Iroquois declared war in 1650 and exterminated the Neutral nation.
In 1784, Captain Joseph Brant and the Six Nations Indians left New York State for Canada. As a reward for their loyalty to the British Crown, they were given a large land grant, referred to as the Haldimand Tract, on the Grand River. The original Mohawk settlement was on the south edge of the present-day city at a location favourable for landing canoes. Brant's crossing of the river gave the original name to the area: Brant's ford. By 1847, European settlers began to settle further up the river at a ford in the Grand River and named the village Brantford. The Mohawk Chapel, part of the original Mohawk settlement, is Ontario's oldest Protestant church. Brantford was incorporated as a city in 1877.
The history of the Brantford region from 1793 to 1920 is described at length in the book At The Forks of The Grand
