Salta was founded on April 16, 1582 by the Spanish conquistador Hernando de Lerma, who intended the settlement to be an outpost between Lima, Peru and Buenos Aires.
During the war of independence, the city became a commercial and military strategic point between Perú and the Argentine cities. Between 1816 and 1821, the city was led by local military leader General Martín Miguel de Güemes, who under the command of General José de San Martín, defended the city and surrounding area from Spanish forces coming from further north.
Salta emerged from the War of Independence politically in disarray and financially bankrupt, a condition that lingered throughout much of the 19th century. However, in the late 19th and early 20th centuries, the arrival of Italian, Spanish and Arab immigrants, particularly Syrians and Lebanese, revived trade and agriculture all over the area while further enhancing the city's multicultural flavor