* Tassili is the recording location and the title of a 2011 album by the Tuareg-Berber band Tinariwen.
* In his 1992 book Food of the Gods, new-age icon Terence McKenna hypothesized that the Neolithic culture that inhabited the site used psilocybin mushrooms as part of its religious ritual life, citing rock paintings showing persons holding mushroom-like objects in their hands, as well as mushrooms growing from their bodies.
* Tassili Plain is a track on the 1994 album Natural Wonders of the World in Dub by dub reggae group Zion Train
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