On the island the predominant religion is Roman Catholicism. Other Christian denominations are also present. Of the churches that present in the Neospartan entity, among the most important are: Bas�lica de la Virgen del Valle (in the Valley of the Esp�ritu Santo), Cathedral of La Asunci�n, Iglesia San Juan Evangelista (en Juangriego), Iglesia parroquial de San Juan (en San Juan Bautista), Iglesia de San Nicol�s de Bari (Porlamar), of the San Jos� de Paraguachi and other churches and chapels minor located in populations of Santa Ana, Punta de Piedras, Porlamar, Pampatar and virtually all the towns of the island. There are also small populations of Jews and Muslims.
Evangelical Christian churches have had a significant growth in recent years demonstrating their presence and impact in the population of the island. One of the fastest-growing is the Centro Cristiano Casa de Alabanza (CCCA), present in Porlamar, Juan Griego, La Asunci�n and Tubores Municipality.
The patron of eastern Venezuela is the Virgen del Valle and in the population El Valle del Esp�ritu Santo is the Bas�lica Menor de Nuestra Se�ora del Valle, which approaching Margarita, Coche and Cubagua Islanders visit to honor her on her feast day