During colonial times the site of Roanoke was an important hub of trails and roads. The Great Wagon Road, one of the most heavily travelled roads of eighteenth century America, ran from Philadelphia through the Shenandoah Valley to the future site of the City of Roanoke, where the Roanoke River passed through the Blue Ridge. The Roanoke Gap proved a useful route for immigrants to settle the Carolina Piedmont region. At Roanoke Gap, another branch of the Great Wagon Road, the Wilderness Road, continued southwest to Tennessee.
In the 1850s, Big Lick became a stop on the Virginia and Tennessee Railroad (V&T) which linked Lynchburg with Bristol on the Virginia-Tennessee border.
After the American Civil War (1861–1865), William Mahone, a civil engineer and hero of the Battle of the Crater, was the driving force in the linkage of 3 railroads, including the V&T, across the southern tier of Virginia to form the Atlantic, Mississippi & Ohio Railroad (AM&O), a new line extending from Norfolk to Bristol, Virginia in 1870. However, the Financial Panic of 1873 wrecked the AM&O's finances. After several years of operating under receiverships, Mahone's role as a railroad builder ended in 1881 when northern financial interests took control. At the
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