Tobacco is one of Prilep's traditional cash crops and prospers in the Macedonian climate. Many of the world's largest cigarette makers, such as Marlboro, West and Camel use Prilep's tobacco in their cigarettes after it is processed in local factories such as Tutunski kombi at Prilep. A Tobacco Institute is established in the city in order to produce new types of tobacco and it was the first example of applying genetics to agriculture in the Balkans
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