Kintetsu operates the Tochinoki overnight highway bus service from Osaka and Kyoto to Utsunomiya Station. It takes 10 hours from Osaka and 8 1/2 hours from Kyoto and costs �11000 and �10400 one way, respectively. This service has been spotty with suspensions; it is usually cheaper and more reliable to take a train to Tokyo Station or Shinjuku station, then to ride a bus to your destination from there.
Mito, the capital of neighboring Ibaraki, has highway bus service connecting with Utsunomiya, with departures hourly in either direction