Cangrande I, only the last shared the government (1308); he was great as warrior, prince, and patron of the arts; he protected Dante, Petrarch, and Giotto. By war or treaty, he brought under his control the cities of Padua (1328), Treviso (1308) and Vicenza.
Alberto was succeeded by Mastino II (1329–1351) and Alberto, sons of Alboino. Mastino continued his uncle's policy, conquering Brescia in 1332 and carrying his power beyond the Po. He purchased Parma (1335) and Lucca (1339). After the King of France, he was the richest prince of his time. But a powerful league was formed against him in 1337 – Florence, Venice, the Visconti, the Este, and the Gonzaga. After a three years war, the Scaliger dominions were reduced to Verona and Vicenza (Mastino's daughter Regina-Beatrice della Scala married to Barnabò Visconti). Mastino's son Cangrande II (1351–1359) was a cruel, dissolute, and suspicious tyrant; not trusting his own subjects, he surrounded himself with Brandenburg mercenaries. He was killed by his brother Cansignorio (1359–1375), who beautified the city with palaces, provided it with aqueducts and bridges, and founded the state treasury. He also killed his other brother, Paolo Alboino. Fratricide seems to have become a family custom, for Antonio (1375–87), Cansignorio's natural brother, slew his brother Bartolomeo, thereby arousing the indignation of the people, who deserted him when Gian Galeazzo Visconti of Milan made war on him. Having exhausted all his resources, he fled from Verona at midnight (19 October 1387), thus putting an end to the Scaliger domination, which, however, survived in its monuments.
The year 1387 is also the year of the famous Battle of Castagnaro, between Giovanni Ordelaffi, for Verona, and John Hawkwood, for Padua, who was the winner.
Antonio's son Canfrancesco in vain attempted to recover Verona (1390).
Guglielmo (1404), natural son of Cangrande II, was more fortunate; with the support of the